Prof. Raju Mukherjee - Metabolic intoxication as a strategy for enhancing antibiotic efficacy

Raju Mukherjee

Indian Institute of Science Education and Research, Tirupati, India

Metabolic intoxication as a strategy for enhancing antibiotic efficacy

The presence of populations of bacteria that are tolerant to antimicrobial killing lengthens the time required for successful treatment and provides bacteria with an opportunity to become resistant. Understanding the mechanism and sequence of adaptive events leading to antibiotic tolerance in mycobacteria is important for increasing the efficacy of antibiotics. This seminar will present the vulnerabilities in mycobacterial energy metabolism and glycogen metabolism, that can be targeted as adjuvant therapeutics to potentiate current anti-TB drugs, minimising drug tolerance and, therefore, the development of antibiotic resistance.

Selected publications

• Lodhiya T, Palande A, Veeram A, Larrouy-Maumus G, Dany J V Beste, Mukherjee R. 2025. ATP burst is the dominant driver of antibiotic lethality in Mycobacteria. Elife, doi.org/10.1101/2023.09.11.557291
• Jain S, Patil,A, Patil S, Mukherjee R , Jain V, Mahalakshmi R. 2025. Mycobacterium tuberculosis TtfA is a highly stable membrane-anchored DNA binding protein. J Membr Biol, doi.org/10.1007/s00232-025-00352-5
• Palande A., Patil S, Veeram A,Saho, S, Lodhiya T, Maurya P, Muralikrishnan B, Chugh J, Mukherjee R. 2024. Proteomic analysis of the Mycobacterium tuberculosis outer membrane for potential implications in uptake of small molecules. ACS Infect Dis, 10(3) 890