Dr. Pierre Verhaeghe - Some useful medicinal chemistry approaches to develop novel anti-infectives

Pierre Verhaeghe

Département de Pharmacochimie Moléculaire (DPM), UMR CNRS 5063, Faculté de Pharmacie, Université Grenoble-Alpes

Some useful medicinal chemistry approaches to develop novel anti-infectives

Anti-infective chemotherapy is constantly threatened by the emergence of drug-resistant pathogens which requires continual research efforts to identify novel chemical entities with original mechanisms of action and/or druggable microbial targets. Based on our experience in the development of new anti-infectives against protozoan parasites such as P. falciparum, Leishmania spp, Trypanosoma spp, or bacteria such as C. difficile and M. tuberculosis, the conference will present three examples of medicinal chemistry strategies that can be useful for the research and study of novel anti-infectives: Simplified bio-inspired chemistry, electrochemistry-assisted prodrug conception and affinity chromatography on immobilized inhibitors.

Selected publications

• Pedron, J. et al. ACS Med Chem Lett 2020, 11, 464-472
• Fersing, C. et al. Eur J Med Chem 2020, 202, 112558
• Salas-Ambrosio, P. et al. J Am Chem Soc 2021, 143, 3697-3702
• Bosson-Vanga, H. et al. Microbiol Spectrum 2021, 9, e00274-21
• Salas-Ambrosio, P. et al. Polym Chem 2022, 13, 600
• Le, N-H. et al. Bioorg Med Chem 2022, 71, 116938